Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC021
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-01-18 08:12
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Tbl Madopar a 250mg 3x1\2 tbl PK Merz a 100mg 1+2+0 tbl Jumex 5mg 1 u 10h

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.68 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.68 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 3, 'TP': 40, 'FP': 27}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 25, 'TP': 15, 'FP': 5}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 14.188
timePerCircleCoV 0.251898
timePerCircleSlope 0.062759
meanError 1.36094
tremorFreq 7.12891
tremorRelPower 27.6572
tremorGyroAmpMean 0.0311948
tremorGyroAmpSlope 0.000735279
tremorGyroAmpCoV 0.350811
tremorCoordAmpMean 0.067324
tremorCoordAmpSlope -0.00131569
tremorCoordAmpCoV 1.60316
tremorAccAmpMean 0.0381528
tremorAccAmpSlope -0.00216791
tremorAccAmpCoV 0.386839
tremorPcRelVar 0.640638
tremorPcX -0.7988
tremorPcY -0.601597

Circle Segment 1

Duration 8.4 s, Accuracy Estimate 1.056 (lower is better)

Circle Segment 2

Duration 10.56 s, Accuracy Estimate 1.131 (lower is better)

Circle Segment 3

Duration 16.76 s, Accuracy Estimate 1.147 (lower is better)

Circle Segment 4

Duration 13.76 s, Accuracy Estimate 1.19 (lower is better)

Circle Segment 5

Duration 11.68 s, Accuracy Estimate 1.324 (lower is better)

Circle Segment 6

Duration 11.2 s, Accuracy Estimate 1.701 (lower is better)

Circle Segment 7

Duration 15.72 s, Accuracy Estimate 1.392 (lower is better)

Circle Segment 8

Duration 17.88 s, Accuracy Estimate 1.395 (lower is better)

Circle Segment 9

Duration 18.92 s, Accuracy Estimate 1.364 (lower is better)

Circle Segment 10

Duration 17.0 s, Accuracy Estimate 1.91 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 51.096
timePerSpiralCoV 0.165137
timePerSpiralSlope 0.0620009
meanError 1.72329
tremorFreq 7.32422
tremorRelPower 29.4624
tremorGyroAmpMean 0.0298609
tremorGyroAmpSlope -0.000581583
tremorGyroAmpCoV 0.47434
tremorCoordAmpMean 0.0484791
tremorCoordAmpSlope -0.00119992
tremorCoordAmpCoV 0.677798
tremorAccAmpMean 0.0373822
tremorAccAmpSlope -0.000769742
tremorAccAmpCoV 0.526063
tremorPcRelVar 0.567137
tremorPcX 0.444909
tremorPcY 0.895576

Spiral Segment 1

Duration 40.16 s, Accuracy Estimate 1.533 (lower is better)

Spiral Segment 2

Duration 46.52 s, Accuracy Estimate 1.548 (lower is better)

Spiral Segment 3

Duration 60.04 s, Accuracy Estimate 1.914 (lower is better)

Spiral Segment 4

Duration 59.0 s, Accuracy Estimate 1.48 (lower is better)

Spiral Segment 5

Duration 49.76 s, Accuracy Estimate 2.142 (lower is better)

Elel

eDurationMean 0.715135
eDurationStd 0.20535
eDurationStdnorm 0.287149
eDurationMedian 0.68
eDurationQuartdelta 0.26875
eDurationQuartdeltanorm 0.395221
eDurationKurt 2.69697
eDurationTrenddiff -0.0175
eDurationTrendratio 0.974729
eWidthMean 4.62624
eWidthStd 1.44526
eWidthStdnorm 0.312405
eWidthMedian 4.212
eWidthQuartdelta 1.1115
eWidthQuartdeltanorm 0.263889
eWidthKurt 4.44704
eWidthTrenddiff -0.0585
eWidthTrendratio 0.985915
eHeightMean 7.73149
eHeightStd 1.44705
eHeightStdnorm 0.187163
eHeightMedian 7.254
eHeightQuartdelta 2.13525
eHeightQuartdeltanorm 0.294355
eHeightKurt 2.03126
eHeightTrenddiff -0.8775
eHeightTrendratio 0.887218
eAspectMean 0.595817
eAspectStd 0.115329
eAspectStdnorm 0.193565
eAspectMedian 0.575
eAspectQuartdelta 0.154589
eAspectQuartdeltanorm 0.268851
eAspectKurt 2.61141
eAspectTrenddiff 0.0415078
eAspectTrendratio 1.07549
eSlantMean 0.202187
eSlantStd 0.115234
eSlantStdnorm 0.569936
eSlantMedian 0.208333
eSlantQuartdelta 0.123219
eSlantQuartdeltanorm 0.59145
eSlantKurt 4.5698
eSlantTrenddiff 0.0507682
eRtopMean 0.788391
eRtopStd 0.0887429
eRtopStdnorm 0.112562
eRtopMedian 0.794118
eRtopQuartdelta 0.121744
eRtopQuartdeltanorm 0.153308
eRtopKurt 2.67374
eRtopTrenddiff -0.0333333
eRbotMean 0.457349
eRbotStd 0.177702
eRbotStdnorm 0.388547
eRbotMedian 0.441176
eRbotQuartdelta 0.186116
eRbotQuartdeltanorm 0.421864
eRbotKurt 10.9488
eRbotTrenddiff -0.096435
eRrightMean 0.860554
eRrightStd 0.0603346
eRrightStdnorm 0.0701113
eRrightMedian 0.87037
eRrightQuartdelta 0.0625
eRrightQuartdeltanorm 0.0718085
eRrightKurt 4.6538
eRrightTrenddiff -0.0297504
eRleftMean 0.261896
eRleftStd 0.0809981
eRleftStdnorm 0.309276
eRleftMedian 0.265306
eRleftQuartdelta 0.103512
eRleftQuartdeltanorm 0.39016
eRleftKurt 3.26614
eRleftTrenddiff -0.00220344
lDurationMean 1.07679
lDurationStd 0.260754
lDurationStdnorm 0.242158
lDurationMedian 1.03
lDurationQuartdelta 0.32375
lDurationQuartdeltanorm 0.31432
lDurationKurt 2.72566
lDurationTrenddiff 0.225
lDurationTrendratio 1.23438
lWidthMean 7.422
lWidthStd 1.0259
lWidthStdnorm 0.138224
lWidthMedian 7.371
lWidthQuartdelta 1.3455
lWidthQuartdeltanorm 0.18254
lWidthKurt 3.16223
lWidthTrenddiff 0.234
lWidthTrendratio 1.03226
lHeightMean 15.885
lHeightStd 1.97326
lHeightStdnorm 0.124222
lHeightMedian 15.327
lHeightQuartdelta 2.95425
lHeightQuartdeltanorm 0.192748
lHeightKurt 2.27086
lHeightTrenddiff -1.872
lHeightTrendratio 0.889655
lAspectMean 0.469848
lAspectStd 0.0567236
lAspectStdnorm 0.120728
lAspectMedian 0.470588
lAspectQuartdelta 0.0783388
lAspectQuartdeltanorm 0.16647
lAspectKurt 2.30995
lAspectTrenddiff 0.0230769
lAspectTrendratio 1.05
lSlantMean 0.267114
lSlantStd 0.065092
lSlantStdnorm 0.243687
lSlantMedian 0.284722
lSlantQuartdelta 0.0965276
lSlantQuartdeltanorm 0.339024
lSlantKurt 3.82353
lSlantTrenddiff 0.0546028
lRtopMean 0.898935
lRtopStd 0.0391885
lRtopStdnorm 0.0435944
lRtopMedian 0.893939
lRtopQuartdelta 0.0505752
lRtopQuartdeltanorm 0.0565757
lRtopKurt 2.72727
lRtopTrenddiff 0.00558943
lRbotMean 0.334977
lRbotStd 0.106756
lRbotStdnorm 0.318698
lRbotMedian 0.314286
lRbotQuartdelta 0.0961859
lRbotQuartdeltanorm 0.306046
lRbotKurt 5.38266
lRbotTrenddiff -0.0245098
lRrightMean 0.940929
lRrightStd 0.0294093
lRrightStdnorm 0.0312555
lRrightMedian 0.945455
lRrightQuartdelta 0.0372742
lRrightQuartdeltanorm 0.0394247
lRrightKurt 2.84685
lRrightTrenddiff 0.00778938
lRleftMean 0.139
lRleftStd 0.050567
lRleftStdnorm 0.36379
lRleftMedian 0.137931
lRleftQuartdelta 0.0602431
lRleftQuartdeltanorm 0.436762
lRleftKurt 4.82609
lRleftTrenddiff 0.00212857

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.88277
sumTouchScores 18.5382
meanMovementTime 0.90425
numTouches 21
undershootPercentage 0
overshootPercentage 23.8095

FITTS Long Modified

meanTouchScore 0.973857
sumTouchScores 12.6601
meanMovementTime 1.46167
numTouches 13
undershootPercentage 0
overshootPercentage 15.3846

ZigZag

numZigzags 5
timePerZigzagMean 43.248
timePerZigzagCoV 0.247567
timePerZigzagSlope 0.11367
meanError 2.03492
tremorFreq 7.61719
tremorRelPower 30.5739
tremorGyroAmpMean 0.0340273
tremorGyroAmpSlope 0.000987628
tremorGyroAmpCoV 0.471825
tremorCoordAmpMean 0.0455989
tremorCoordAmpSlope -0.000593935
tremorCoordAmpCoV 0.431581
tremorAccAmpMean 0.0567262
tremorAccAmpSlope -0.000313474
tremorAccAmpCoV 0.211136
tremorPcRelVar 0.696512
tremorPcX 0.211027
tremorPcY -0.97748

ZigZag Segment 1

Duration 25.16 s, Accuracy Estimate 2.062 (lower is better)

ZigZag Segment 2

Duration 43.92 s, Accuracy Estimate 1.92 (lower is better)

ZigZag Segment 3

Duration 52.88 s, Accuracy Estimate 1.94 (lower is better)

ZigZag Segment 4

Duration 45.16 s, Accuracy Estimate 1.895 (lower is better)

ZigZag Segment 5

Duration 49.12 s, Accuracy Estimate 2.358 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 36.808
timePerZigzagCoV 0.142664
timePerZigzagSlope 0.047707
zigzagHeightMean 67.0706
zigzagHeightCoV 0.0325392
zigzagHeightSlope -0.0199627
meanError 0.0435669
tremorFreq 7.61719
tremorRelPower 30.1357
tremorGyroAmpMean 0.0386137
tremorGyroAmpSlope -0.000793783
tremorGyroAmpCoV 0.423843
tremorCoordAmpMean 0.0541095
tremorCoordAmpSlope -0.0016466
tremorCoordAmpCoV 0.385296
tremorAccAmpMean 0.0626323
tremorAccAmpSlope -0.000654253
tremorAccAmpCoV 0.22442
tremorPcRelVar 0.715998
tremorPcX 0.147134
tremorPcY -0.989117

ZigZag Offset Segment 1

Duration 29.44 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 2

Duration 38.28 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 3

Duration 36.96 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 4

Duration 44.0 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 5

Duration 35.36 s, Accuracy Estimate 0.058 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.68}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.3061117578513599}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8993730331059078}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}